A framework for prescription in exercise-oncology research
John P Sasso1, Neil D Eves2, Jesper F Christensen3
1Memorial Sloan Kettering Cancer Centre, New York, NY, USA.
Journal of Cachexia, Sarcopenia and Muscle
|July 3, 2015
Summary
Applying fundamental exercise physiology principles to exercise oncology research can unlock the full therapeutic potential of exercise for cancer patients. Optimizing exercise prescriptions enhances safety and efficacy in cancer care.
Area of Science:
- Exercise Oncology
- Cancer Rehabilitation
- Human Exercise Physiology
Background:
- Exercise oncology research has grown significantly, with numerous studies evaluating structured exercise interventions for cancer patients.
- Most studies use traditional, moderate-intensity aerobic or combined endurance/resistance training, adhering to general guidelines.
Discussion:
- Generic exercise prescriptions may limit the full therapeutic benefits of exercise in cancer care.
- This paper reviews core principles of human exercise physiology relevant to exercise oncology.
Key Insights:
- Applying principles of training (e.g., specificity, overload, progression) is crucial for designing effective exercise interventions.
- Tailoring exercise prescriptions based on physiological principles can optimize outcomes for cancer survivors.
Outlook:
- Implementing these principles in clinical trials will advance exercise oncology research.
- Optimized exercise strategies promise to improve safety and efficacy of exercise as a supportive cancer treatment.
Related Concept Videos
01:02Prescription, Nonprescription and Orphan Drugs
1.4K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
1.4K
01:28Dosage Regimens: Designs and Approaches
483
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
483
01:11Clinical Trials: Overview
5.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.5K
01:21Drug Dosing: Obese Patients
345
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
345
01:26Drug Administration and Therapy Phases: Overview
1.7K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.7K
01:16Clinical Trials
11.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
11.2K