Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Characterizing the Role of daf-16/C. elegans FOXO in Lifespan and Healthspan.

Methods in molecular biology (Clifton, N.J.)·2024

Same author

Editorial: Year in review: discussions in genetics of aging.

Frontiers in genetics·2024

Same author

Glucose-fed microbiota alters C. elegans intestinal epithelium and increases susceptibility to multiple bacterial pathogens.

Scientific reports·2024

Same author

SIRT1, resveratrol and aging.

Frontiers in genetics·2024

Same author

Bacterial processing of glucose modulates C. elegans lifespan and healthspan.

Scientific reports·2021

Same author

Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in <i>Caenorhabditis elegans</i>.

Proceedings of the National Academy of Sciences of the United States of America·2018

Same journal

Fine structure of the subitaneous eggshell of the sessile rotifer <i>Stephanoceros millsii</i> (Monogononta) with observations on vesicle trafficking in the integument during ontogeny.

Invertebrate reproduction & development·2019

Same journal

Invertebrates as model organisms for research on aging biology.

Invertebrate reproduction & development·2015

Same journal

Exploring the physiology and pathology of aging in the intestine of <i>Drosophila melanogaster</i>.

Invertebrate reproduction & development·2015

Same journal

Aging in the colonial chordate, <i>Botryllus schlosseri</i>.

Invertebrate reproduction & development·2015

Same journal

<i>Hydra</i> as a tractable, long-lived model system for senescence.

Invertebrate reproduction & development·2015

Same journal

<i>Botryllus schlosseri</i>, an emerging model for the study of aging, stem cells, and mechanisms of regeneration.

Invertebrate reproduction & development·2015

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Apr 7, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Using C. elegans for aging research.

Heidi A Tissenbaum¹

¹Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School , Worcester , MA 01605 , USA.

Invertebrate Reproduction & Development

|July 3, 2015

Summary

This summary is machine-generated.

The nematode Caenorhabditis elegans (C. elegans) is a key model organism for aging research. This review explores its genetic mutants and discusses its utility in understanding human aging.

Keywords:

C. elegans aging dauer insulin/IGF-1 longevity

More Related Videos

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Related Experiment Videos

Last Updated: Apr 7, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Area of Science:

Developmental Biology
Genetics
Gerontology

Background:

Caenorhabditis elegans (C. elegans) was first identified over a century ago.
Sydney Brenner proposed C. elegans as a model organism in 1963 due to its suitability for lab research.
C. elegans has become a premier model system for aging research.

Purpose of the Study:

To review initial identification of C. elegans mutants with altered lifespans, focusing on genetics.
To discuss the advantages and disadvantages of using C. elegans for human aging research.
To focus on the molecular genetics aspects of C. elegans in aging research.

Main Methods:

Literature review of C. elegans mutants affecting lifespan.
Analysis of genetic factors influencing aging in C. elegans.
Comparative discussion of C. elegans as a model for human aging.

Main Results:

Identification of mutants with altered lifespans in C. elegans.
Exploration of the genetic basis for lifespan regulation in C. elegans.
Evaluation of C. elegans's strengths and weaknesses as a model for human aging.

Conclusions:

C. elegans is a valuable model organism for aging research due to its genetic tractability.
Understanding C. elegans aging mechanisms provides insights into human aging.
Further research into C. elegans molecular genetics can advance gerontological studies.