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Protective effect of probiotics in the treatment of infantile eczema

Rong-Jun Lin1, Li-Hua Qiu2, Ren-Zheng Guan1

  • 1Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China.

Experimental and Therapeutic Medicine
|July 3, 2015
PubMed

Insights

Probiotic supplementation with Bifidobacterium bifidum effectively reduced eczema severity in infants. This study shows probiotics can help manage infantile eczema by improving gut bacteria and lowering the Scoring Atopic Dermatitis index.

Area of Science:

  • Microbiology
  • Pediatric Dermatology
  • Gastroenterology

Background:

  • Infantile eczema is a common condition with complex causes.
  • Gut microbiota alterations are implicated in atopic dermatitis.
  • Probiotics may modulate the immune response and gut environment.

Purpose of the Study:

  • To investigate the efficacy of Bifidobacterium bifidum in treating infantile eczema.
  • To assess changes in intestinal Bifidobacteria levels and SCORAD index.
  • To provide evidence for probiotic application in eczema prevention and treatment.

Main Methods:

  • Randomized controlled trial with 40 infants diagnosed with eczema.
  • Treatment group received B. bifidum capsules; control group received placebo.
  • Quantification of B. bifidum in stool using 16S rRNA/DNA qPCR.
  • Evaluation of Scoring Atopic Dermatitis (SCORAD) index before and after 4 weeks of treatment.

Main Results:

  • B. bifidum levels significantly increased in the treatment group (P<0.05).
  • SCORAD index significantly decreased in the treatment group (P<0.05).
  • No significant changes in B. bifidum or SCORAD index were observed in the control group.
  • Post-treatment B. bifidum levels were higher and SCORAD index lower in the treatment group compared to controls (P<0.05).

Conclusions:

  • Probiotic supplementation with B. bifidum demonstrates a positive effect on infantile eczema.
  • B. bifidum may be beneficial in both preventing and treating infantile eczema.
  • Modulating gut microbiota with probiotics offers a potential therapeutic strategy for eczema.

Keywords:
Bacillus bifiduseczemainfantsprobiotics

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