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Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery
Tiandong Li1, Hongmin Bai1, Guoliang Wang1
1Department of Neurosurgery, Liuhuaqiao Hospital, Guangzhou, Guangdong 510010, P.R. China.
Experimental and Therapeutic Medicine
|July 3, 2015
Summary
Direct electrical stimulation (DES) reliably maps brain language areas during glioma surgery. This method allows for safe tumor resection while preserving crucial language functions, minimizing postoperative deficits.
Area of Science:
- Neurosurgery
- Neuroscience
- Oncology
Background:
- Glioma surgery requires precise mapping of critical brain functions.
- Direct electrical stimulation (DES) is a technique used for intraoperative brain mapping.
Purpose of the Study:
- To investigate the application and significance of DES for mapping language functions during glioma surgery.
- To evaluate the safety and efficacy of DES in gliomas located in or near language areas.
Main Methods:
- Retrospective analysis of clinical data from 91 patients undergoing glioma surgery with DES.
- Cortical electrical stimulation and intraoperative brain mapping of language functions.
- Postoperative assessment of neurological function and imaging review.
Main Results:
- DES successfully identified language areas, with counting interruptions observed in specific left hemisphere regions.
- Most patients (46.2%) had no postoperative neurological dysfunction; brief language or limb movement disorders were common but transient.
- Tumor excision (overall or sub-overall) was achieved in 84 out of 91 cases.
Conclusions:
- Direct electrical stimulation is a reliable and noninvasive method for intraoperative language area localization during glioma surgery.
- DES facilitates maximal safe resection of gliomas within or adjacent to eloquent language cortices.
- The technique contributes to improved patient outcomes by minimizing neurological deficits.
