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MicroRNAs as potential target in human bone and soft tissue sarcoma therapeutics

Jyotika Varshney1, Subbaya Subramanian2

  • 1Department of Surgery, University of Minnesota Minneapolis, MN, USA.

Frontiers in Molecular Biosciences
|July 3, 2015
PubMed

Insights

MicroRNAs show promise as diagnostic and therapeutic targets for aggressive sarcomas. Targeting these deregulated microRNAs could lead to improved treatments for various human sarcomas.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Sarcomas are aggressive, heterogeneous tumors of mesenchymal origin with limited targeted therapy options.
  • Despite advancements in diagnostic markers like chromosomal translocations, effective treatments remain challenging due to tumor complexity.
  • MicroRNAs (miRNAs), a class of small non-coding RNAs, are emerging as significant biomarkers in sarcoma.

Purpose of the Study:

  • To review the current understanding of microRNA deregulation in various sarcoma types.
  • To explore strategies for targeting microRNAs as a therapeutic approach for sarcomas.

Main Methods:

  • Literature review of studies on microRNA expression and function in sarcomas.
  • Analysis of current therapeutic strategies targeting microRNAs in cancer research.

Main Results:

  • MicroRNAs are frequently deregulated across different sarcoma subtypes, impacting tumor progression.
  • Specific microRNAs show potential as diagnostic and prognostic biomarkers.
  • Targeting oncogenic or tumor-suppressive microRNAs presents a viable therapeutic avenue.

Conclusions:

  • MicroRNAs represent a promising class of molecules for developing novel diagnostic and therapeutic strategies in sarcoma.
  • Further research into miRNA-based therapies could significantly improve treatment outcomes for sarcoma patients.
Keywords:
bone sarcomamicroRNAsosteosarcomapediatric oncologysarcomasoft tissue sarcomatherapeutics

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