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Fanning the Fire: Can Methemoglobin Enhance Neutrophil Activation?

Julie A Bastarache1, James L Wynn2, Lorraine B Ware3

  • 1Division of Allergy, Pulmonary, and Critical Care Medicine, USA.

Ebiomedicine
|July 3, 2015
PubMed
Abstract

No abstract available in PubMed .

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Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
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