Physical Function, Hyperuricemia, and Gout in Older Adults.
Bridget Teevan Burke1, Anna Köttgen2, Andrew Law1
1Johns Hopkins University, Baltimore, Maryland.
Arthritis Care & Research
|July 4, 2015
Summary
Older adults with gout experience worse lower extremity function, impacting mobility and performance. Hyperuricemia also correlates with diminished physical function in this age group.
Area of Science:
- Gerontology
- Rheumatology
- Epidemiology
Background:
- Gout is prevalent in older adults, increasing their risk of physical disability.
- The impact of gout and hyperuricemia on physical function in seniors remains unclear.
Purpose of the Study:
- To investigate the association between gout, hyperuricemia, and physical function in adults aged 65 and older.
- To determine if gout or hyperuricemia affects lower extremity function (Short Physical Performance Battery, walking speed) and upper extremity function (grip strength).
Main Methods:
- Analysis of data from 5,819 older adults in the Atherosclerosis Risk in Communities Study (2011-2013).
- Assessment of lower extremity function using SPPB and 4-meter walking speed.
- Evaluation of upper extremity function via grip strength, with statistical adjustments for confounding factors.
Main Results:
- Participants with gout showed significantly worse performance on SPPB and slower walking speed.
- Gout history was associated with a higher likelihood of poor physical performance in lower extremities.
- Hyperuricemia was also linked to worse SPPB scores and walking speed, but not grip strength.
Conclusions:
- Older adults with gout and hyperuricemia exhibit poorer lower extremity function.
- Gout and hyperuricemia do not appear to significantly affect upper extremity function (grip strength) in this population.
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