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BMP2 Is Associated with Caries Experience in Primary Teeth
Helena Freire Romanos1, Leonardo Santos Antunes, Ludiana Barbosa Lopes
1Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
Caries Research
|July 4, 2015
Summary
Genetic variations in Bone Morphogenetic Protein 2 (BMP2) may influence caries experience in primary teeth. This study found a link between BMP2 polymorphisms and caries susceptibility in a Brazilian cohort, but not enamel microhardness.
Area of Science:
- Genetics and Dental Research
- Enamel Development and Caries Susceptibility
Background:
- Bone morphogenetic proteins (BMPs) are crucial for enamel development.
- BMPs' role in caries susceptibility warrants investigation due to their developmental importance.
- Specific BMP gene polymorphisms (BMP2, BMP4, BMP7) are examined for associations with dental caries.
Purpose of the Study:
- To investigate the association between polymorphisms in BMP2, BMP4, and BMP7 genes and caries experience.
- To evaluate the relationship between these BMP gene polymorphisms and primary enamel microhardness.
- To analyze genetic data from 1,731 subjects across three Brazilian datasets.
Main Methods:
- Genomic DNA was extracted from buccal cells of 1,731 participants.
- Polymorphisms in BMP2, BMP4, and BMP7 genes were analyzed using real-time polymerase chain reaction.
- Statistical analyses, including chi-squared tests, logistic regression, and transmission disequilibrium tests, were employed to assess associations with caries experience and enamel microhardness.
Main Results:
- A statistically significant association was found between BMP2 gene polymorphisms and caries experience in the primary dentition of the Nova Friburgo cohort (p = 0.023; OR = 2.58).
- No significant associations were observed between BMP gene polymorphisms (BMP2, BMP4, BMP7) and primary enamel microhardness alterations.
- Differences in caries experience related to certain risk factors were statistically significant.
Conclusions:
- The BMP2 gene may play a role in caries experience in primary dentition.
- BMP gene polymorphisms do not appear to influence primary enamel microhardness.
- Further research is needed to elucidate the specific mechanisms linking BMP2 to caries development.
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