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Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma

Sadakatsu Ikeda1, Donna E Hansel2, Razelle Kurzrock1

  • 1Department of Medicine, Division of Hematology/Oncology, and Center for Personalized Cancer Therapy, UC San Diego Moores Cancer Center, La Jolla, CA, USA.

Cancer Treatment Reviews
|July 4, 2015
PubMed

Insights

Advanced urothelial carcinoma shows numerous genomic aberrations. Novel targeted therapies and immunotherapy offer potential treatment strategies for these aggressive cancers.

Area of Science:

  • Oncology
  • Genomics
  • Cancer Research

Background:

  • Advanced urothelial carcinoma presents a significant therapeutic challenge with limited improvements from traditional chemotherapy.
  • Genomic analysis technologies have advanced, enabling detailed characterization of tumor alterations.

Purpose of the Study:

  • To review the genomic landscape of malignant urothelial carcinomas.
  • To explore the potential of targeted therapies and immunotherapy for urothelial carcinoma based on identified genomic alterations.

Main Methods:

  • Review of The Cancer Genome Atlas (TCGA) data for muscle-invasive urothelial carcinoma.
  • Analysis of frequently altered genes including TP53, ARID1A, PIK3CA, ERCC2, FGFR3, and HER2.

Main Results:

  • TCGA identified numerous genomic aberrations in urothelial carcinoma.
  • Specific genetic alterations like TP53, ARID1A, PIK3CA, ERCC2, FGFR3, and HER2 are prevalent.

Conclusions:

  • The genomic profile of urothelial carcinoma presents opportunities for novel therapeutic interventions.
  • Targeted agents and immunotherapy may be effective in selected patient populations with specific genetic alterations.
Keywords:
Genetic aberrationsImmune therapyTargeted therapyUrothelial carcinoma

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