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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Photoreceptors and Visual Pathways01:22

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
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Related Experiment Video

Updated: Apr 7, 2026

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
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SSRI-associated optic neuropathy.

J Lochhead1

  • 1Department of Ophthalmology, St Mary's Hospital, Newport, IOW, UK.

Eye (London, England)
|July 4, 2015
PubMed
Summary

Selective serotonin reuptake inhibitors (SSRIs) may be linked to optic neuropathy (ON). Early cessation of SSRIs might preserve vision and potentially aid recovery in patients experiencing ON.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for depression and anxiety.
  • While ophthalmic side effects like glaucoma are known, optic neuropathy (ON) has not been commonly reported with SSRI use.

Observation:

  • Five cases of optic neuropathy (ON) were identified in an island population over two years.
  • These cases exhibited characteristics potentially associated with long-term SSRI treatment.
  • Vascular origin was suspected for the ON, with Naranjo algorithm scores indicating possible to probable adverse drug reactions.

Findings:

  • SSRI cessation may be beneficial in protecting the unaffected eye.
  • Vision recovery is possible in some cases following SSRI discontinuation.

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  • A potential mechanism involving raised serotonin levels and ischemic optic neuropathy (ION) has been proposed.

    • Implications:

    • The findings suggest a possible link between SSRI use and optic neuropathy.
    • A review of SSRI treatment is recommended for patients presenting with acute ON.
    • Further research is warranted to explore the association between SSRIs and ischemic optic neuropathy.