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Updated: Apr 7, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
An adolescent with hereditary spherocytosis who presented with splenic infarction
Lara Jones1, Zafer Refai1, Mike Linney1
1Department of Paediatrics, Western Sussex Hospitals NHS Foundation Trust, Chichester, UK.
Abstract:
A 16-year-old male patient with known hereditary spherocytosis presented with a 4-day history of chest pain and lethargy. On admission, he had a low-grade fever and was grossly anaemic; examination revealed splenomegaly. An ultrasound scan confirmed splenomegaly with areas of splenic infarction. Subsequent tests suggested possible Epstein-Barr virus infection. The patient recovered well and had a functional spleen on discharge. This case report presents an unusual complication of isolated hereditary spherocytosis.
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