Related Experiment Video
Updated: Apr 7, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Postnatal acute renal failure after fetal exposure to angiotensin receptor blockers
Luca Marchetto1, Desiree Sordino2, Giuseppe De Bernardo3
1Children and Women's Health Department, Medical School University of Padua, Padua, Italy.
Maternal hypertensive treatment with angiotensin receptor blockers (ARBs) during the second and third trimester of pregnancy is associated with several fetal and neonatal complications, and potential adverse outcomes. We report a neonate presenting with transient renal acute failure during the first days of life after maternal treatment with ARBs. Women who became pregnant while taking one of these drugs must modify antihypertensive therapy with a different class drug as soon as pregnancy is recognised.
Maternal hypertensive treatment with angiotensin receptor blockers (ARBs) during the second and third trimester of pregnancy is associated with several fetal and neonatal complications, and potential adverse outcomes. We report a neonate presenting with transient renal acute failure during the first days of life after maternal treatment with ARBs. Women who became pregnant while taking one of these drugs must modify antihypertensive therapy with a different class drug as soon as pregnancy is recognised.
Related Concept Videos
Acute Kidney Injury II: Pathophysiology
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Acute Kidney Injury I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury III: Clinical Manifestations
Antihypertensive Drugs: Direct Renin Inhibitors

