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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
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Occult hepatitis B virus infection in Egypt
Ashraf Elbahrawy1, Alshimaa Alaboudy1, Walid El Moghazy1
1Ashraf Elbahrawy, Ahmed Elwassief, Ahmed Alashker, Abdallah Mahmoud Abdallah, Department of Internal Medicine, Al-Azhar School of Medicine, Al-Azhar University, Cairo 11884, Egypt.
World Journal of Hepatology
|July 4, 2015
Summary
Occult hepatitis B virus (HBV) infection is clinically significant, impacting transmission and liver disease. Egyptian studies show HBV genotype D is prevalent in occult HBV, particularly in specific patient groups.
Area of Science:
- Hepatology
- Virology
- Epidemiology
Background:
- Occult hepatitis B virus (HBV) infection (OBI) presents emerging clinical importance.
- OBI influences infection transmission, liver disease progression, hepatocellular carcinoma, and reactivation risks.
Purpose of the Study:
- To review and clarify the epidemiology of OBI in Egypt.
- To identify patient groups at higher risk for OBI in the Egyptian population.
Main Methods:
- A comprehensive review of the MEDLINE database was conducted.
- Relevant articles focusing on OBI in Egyptian populations were analyzed.
Main Results:
- Hepatitis B virus (HBV) genotype D is the sole genotype detected in Egyptian OBI patients.
- Elevated OBI rates were observed in Egyptian patients with chronic hepatitis C (HCV), those undergoing hemodialysis, children with malignancies, and individuals with cryptogenic liver disease.
- Evidence indicates OBI reactivation following chemotherapy.
Conclusions:
- Routine OBI screening is recommended for Egyptian patients with chronic HCV, on hemodialysis, children with malignant disorders, and those with cryptogenic liver disease.
- Further research is necessary to understand OBI epidemiology in vaccinated Egyptian youth.
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