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[Fibronectin: an early marker of pre-eclampsia]
Plasma fibronectin concentration was determined by immuno-nephelometer analysis in 316 pregnant women between 22 and 38 weeks. The plasma fibronectin concentration increases progressively during normal pregnancy. From 22 to 30 weeks, the 90th percentile is 350 mg/l, and from 30 to 38 weeks it is 400 mg/l. 29 patients had a fibronectin level greater than 400 mg/l. Of this group, 95% of the creatinine's clearance were significantly lowered. From 30 weeks of gestation, the correlation between an elevated level of fibronectin and the development of hypertension is 100%. Our results confirm that this glycoprotein may be an early indicator of preeclampsia.
Plasma fibronectin concentration was determined by immuno-nephelometer analysis in 316 pregnant women between 22 and 38 weeks. The plasma fibronectin concentration increases progressively during normal pregnancy. From 22 to 30 weeks, the 90th percentile is 350 mg/l, and from 30 to 38 weeks it is 400 mg/l. 29 patients had a fibronectin level greater than 400 mg/l. Of this group, 95% of the creatinine's clearance were significantly lowered. From 30 weeks of gestation, the correlation between an elevated level of fibronectin and the development of hypertension is 100%. Our results confirm that this glycoprotein may be an early indicator of preeclampsia.