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Is Daytime Systolic Load an Important Risk Factor for Target Organ Damage in Pediatric Hypertension?

Seçil Conkar1, Ebru Yılmaz2, Şükriye Hacıkara1

  • 1Department of Pediatric Nephrology, Ege University Medical Faculty, Izmir, Turkey.

Journal of Clinical Hypertension (Greenwich, Conn.)
|July 4, 2015
PubMed

Insights

Children with hypertension show target organ damage, particularly with high systolic blood pressure loads. Ambulatory blood pressure monitoring (ABPM) helps identify risks like retinopathy and increased carotid intima-media thickness (cIMT).

Area of Science:

  • Pediatrics
  • Cardiology
  • Nephrology

Background:

  • Hypertension in children is a growing concern.
  • Office blood pressure (BP) measurements may not fully capture BP variability.
  • Ambulatory blood pressure monitoring (ABPM) provides a comprehensive assessment of BP patterns.

Purpose of the Study:

  • To compare ABPM data with target organ damage in children.
  • To identify which hypertension type is a risk factor for target organ damage.

Main Methods:

  • Studied 82 children with suspected hypertension confirmed by ABPM.
  • Assessed target organ damage including hypertensive retinopathy, microalbuminuria, left ventricular mass index, carotid intima-media thickness (cIMT), augmentation index (AIx), and pulse wave velocity (PWV).

Main Results:

  • Significant associations were found between BP load, PWV, and cIMT.
  • Daytime systolic BP load correlated significantly with PWV, AIx, and cIMT.
  • Nighttime BP load (systolic and diastolic) showed significant differences with PWV, AIx, and cIMT.

Conclusions:

  • Target organ damage is more prevalent in children with primary hypertension and elevated systolic BP loads.
  • ABPM is crucial for identifying children at risk for hypertension-related complications.

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