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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Related Experiment Video

Updated: Apr 7, 2026

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

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AIMing 2 Curtail Cancer.

Leah M Rommereim1, Naeha Subramanian1

  • 1Institute for Systems Biology, Seattle, WA 98101, USA.

Cell
|July 4, 2015
PubMed
Summary
This summary is machine-generated.

The inflammasome AIM2 sensor is crucial for maintaining gut health by regulating microbes and stem cells. This discovery offers new insights into protecting against colorectal cancer through innate immunity.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Microbiology

Background:

  • Gut microbiota and innate immunity are vital for health.
  • Dysregulation contributes to complex diseases like colorectal cancer.

Purpose of the Study:

  • To investigate the role of the intracellular innate sensor AIM2 in gut homeostasis.
  • To understand AIM2's function in protecting against colorectal cancer.

Main Methods:

  • Analysis of AIM2's regulation of microbial populations.
  • Assessment of AIM2's impact on intestinal stem cell function.
  • Evaluation of AIM2's role in colorectal cancer development.

Main Results:

  • AIM2 (Absent in Melanoma 2) was found to regulate both microbial and stem cell homeostasis in the gut.
  • This regulation by AIM2 is protective against the development of colorectal cancer.

Conclusions:

  • AIM2 is a key intracellular sensor linking microbial and stem cell balance in the gut.
  • Targeting AIM2 pathways may offer novel strategies for colorectal cancer prevention and treatment.