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Platelets and Their Interactions with Other Immune Cells

Fong W Lam1,2, K Vinod Vijayan1,3,2,4, Rolando E Rumbaut1,3,2

  • 1Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.

Comprehensive Physiology
|July 4, 2015
PubMed

Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions.

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