Related Experiment Video
Updated: Jul 28, 2026
07:40
A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
Subarachnoid hemorrhage in ten questions
M Edjlali1, C Rodriguez-Régent2, J Hodel3
1Inserm UMR 894, Department of Neuroradiolgy, Faculty of Medicine Paris Descartes University, Pyschiatry and Neurosciences Centers, Sainte-Anne Hospital, Sorbonne Paris Cité, 1, rue Cabanis, 75014 Paris, France; Department of Neuroradiology, Lille Nord de France University, Roger Salengro Hospital, Lille University Hospitals, avenue Émile-Laine, 59037 Lille cedex, France.
Diagnostic and Interventional Imaging
|July 5, 2015
Summary
Subarachnoid hemorrhage (SAH) is a serious condition often caused by ruptured aneurysms. Early diagnosis using CT angiography or MRI with FLAIR imaging is crucial for patient outcomes.
Area of Science:
- Neurology
- Radiology
- Neurosurgery
Background:
- Traumatic subarachnoid hemorrhage (SAH) affects 9 in 100,000 people annually.
- SAH carries a high mortality rate, with 40% of deaths occurring within 48 hours.
- Ruptured intracranial aneurysms are the cause in 85% of SAH cases.
Observation:
- Early diagnosis (within 24 hours) of SAH relies on cerebral CT and CT angiography.
- Cerebral MRI can be used if the patient's condition permits.
- FLAIR MRI demonstrates SAH with higher sensitivity than CT, especially in cortical sulci.
Findings:
- CT angiography is recommended for diagnosing SAH and identifying aneurysms.
- FLAIR imaging enhances the detection of SAH in specific locations.
- Lumbar puncture is indicated when initial imaging is inconclusive but clinical suspicion remains high.
Implications:
- Timely and accurate diagnosis of SAH is critical for effective management.
- Advanced imaging techniques like FLAIR MRI improve diagnostic sensitivity.
- A multimodal diagnostic approach ensures comprehensive SAH evaluation.
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:22Aneurysm IV: Nursing Management
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...