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Remodeling and Repair in Rhinosinusitis
Jean-Baptiste Watelet1, Jean-Michel Dogne, François Mullier
1Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, De Pintelaan, 185, 9000, Ghent, Belgium, jeanbaptiste.watelet@ugent.be.
Current Allergy and Asthma Reports
|July 5, 2015
Summary
Chronic rhinosinusitis (CRS) remodeling involves structural tissue changes, differing between CRS with polyps and without. Understanding these changes aids in developing new therapies for upper airway inflammation.
Area of Science:
- Immunology
- Pathology
- Otolaryngology
Background:
- Remodeling in chronic rhinosinusitis (CRS) involves irreversible structural tissue changes.
- Epithelial and extracellular matrix alterations are common in upper airway inflammation but vary in CRS.
- Remodeling in CRS occurs concurrently with inflammation, not just sequentially.
Purpose of the Study:
- To differentiate CRS subtypes based on remodeling patterns.
- To explore the relationship between CRS and asthma.
- To optimize CRS classification and staging for novel therapeutic development.
Main Methods:
- Comparative analysis of tissue structural changes in different CRS subtypes.
- Investigation of factors influencing upper airway remodeling.
- Exploration of CRS subgroups and their association with asthma.
Main Results:
- Edema distinguishes Caucasian eosinophilic CRS with polyps from CRS without polyps (fibrotic changes).
- Specific remodeling associations within CRS are identifiable.
- Ongoing research focuses on factors like coagulation factors, cytokines, growth factors, and proteases.
Conclusions:
- CRS remodeling is complex and linked to inflammation.
- Further research into CRS subtypes and asthma links is crucial for improved classification and therapies.
- Optimizing CRS staging may lead to more effective treatment strategies.
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