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Related Concept Videos

The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Related Experiment Video

Updated: Apr 7, 2026

Investigation of the Electrophysiological and Thermographic Safety Parameters of Surgical Energy Devices During Thyroid and Parathyroid Surgery in a Porcine Model
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Parathyroid function following total thyroidectomy using energy devices.

Fatih Ciftci1, Erdal Sakalli2, Ibrahim Abdurrahman3

  • 1Gelisim University, Vocational school of health services, Istanbul, Turkey.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|July 5, 2015
PubMed
Summary
This summary is machine-generated.

This study compared LigaSure precise (LP) and harmonic scalpel (HS) in thyroidectomy, finding HS initially impaired parathyroid hormone levels more than LP. However, both devices maintained normal levels long-term, with no significant late differences in hormone or calcium levels.

Keywords:
Harmonic scalpelHypocalcemiaHypoparathyroidismLigaSureThyroidectomy

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Area of Science:

  • Endocrine Surgery
  • Surgical Technology
  • Thyroidology

Background:

  • Energy-based devices like LigaSure precise (LP) and harmonic scalpel (HS) are utilized in thyroidectomy.
  • Assessing the impact of these devices on post-operative parathyroid function is crucial for patient outcomes.

Purpose of the Study:

  • To compare the effects of LigaSure precise (LP) versus harmonic scalpel (HS) on parathyroid function after total thyroidectomy.
  • To evaluate early and late post-operative intact parathyroid hormone (iPTH) and serum calcium levels.

Main Methods:

  • A prospective study involving 201 patients undergoing total thyroidectomy, divided into LP (104 patients) and HS (97 patients) groups.
  • Serial measurements of intact parathyroid hormone (iPTH) and serum calcium levels were performed to monitor hypoparathyroidism.
  • Calcium replacement therapy and treatment duration were recorded.

Main Results:

  • Early iPTH levels were significantly lower in the harmonic scalpel (HS) group (17 pg/mL) compared to the LigaSure precise (LP) group (29 pg/mL) (p < 0.001).
  • Despite lower early levels, iPTH remained within normal reference intervals for both groups.
  • No statistically significant differences were observed in late iPTH or early/late serum calcium levels between the LP and HS groups. However, calcium replacement was higher and treatment duration longer in the HS group (p < 0.05).

Conclusions:

  • While harmonic scalpel (HS) initially showed a greater impact on parathyroid hormone levels compared to LigaSure precise (LP), both devices maintained levels within normal limits.
  • Long-term parathyroid function and serum calcium levels were not significantly different between the two devices.
  • The study suggests comparable long-term outcomes regarding parathyroid function between LP and HS in total thyroidectomy.