Determining Complex Genetic Risks by Computer
Related Experiment Video
Updated: Apr 7, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Pamela Flodman1, Susan E Hodge
1Department of Pediatrics, University of California Irvine Medical Center, Orange, California, pflodman@uci.edu.
Abstract:
Genetic risk analysis is a frequent and important responsibility for genetic counselors. Computer-based methods of determining risk are available but not generally used. In this paper, we present a computer-based likelihood approach for performing risk calculations (including Bayesian analysis), and the implementation of this approach using the CYRILLIC and LINKAGE computer packages. Several concrete examples are given, and caveats (which can also be applied to other programs for risk calculation) are discussed.
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