Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.7K
Genetic Screens02:46

Genetic Screens

5.9K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.9K
Probability Laws01:49

Probability Laws

45.1K
Overview
45.1K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

88
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
88
Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

119
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
119

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic counseling program director competencies as proposed by the program leadership development subcommittee of the Genetic Counselor Educators Association.

Journal of genetic counseling·2025
Same author

Ethno-racial differences in the frequency of cancer reported from family pedigrees in the prenatal genetic counseling setting.

Journal of genetic counseling·2025
Same author

Molecular Classes and Growth Hormone Treatment Effects on Behavior and Emotion in Patients with Prader-Willi Syndrome.

Journal of clinical medicine·2022
Same author

Influence of molecular classes and growth hormone treatment on growth and dysmorphology in Prader-Willi syndrome: A multicenter study.

Clinical genetics·2021
Same author

Ethnic disparities in the frequency of cancer reported in family histories.

Journal of genetic counseling·2020
Same author

Molecular subtype and growth hormone effects on dysmorphology in Prader-Willi syndrome.

American journal of medical genetics. Part A·2019
Same journal

Psychosocial aspects of RUNX1-familial platelet disorder in adolescents and young adults: "The fear of knowing it could happen sometime down the road".

Journal of genetic counseling·2026
Same journal

Understanding risk perception and risk-reducing decision-making for surgery among individuals with a genetic predisposition to epithelial ovarian cancer.

Journal of genetic counseling·2026
Same journal

The expected utility and psychological impacts of exome sequencing results in the DDD-Africa study.

Journal of genetic counseling·2026
Same journal

Knowledge, acceptance, and willingness to pay for expanded carrier screening among obstetric patients in China: Implications for genetic counseling practice.

Journal of genetic counseling·2026
Same journal

A pilot qualitative study of patient understanding and perceptions of genetic counselors and cascade testing in the context of transthyretin cardiac amyloidosis.

Journal of genetic counseling·2026
Same journal

Establishment of the genetic counselor profession in Ukraine: Present challenges and prospective pathways.

Journal of genetic counseling·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K

Determining Complex Genetic Risks by Computer.

Pamela Flodman1, Susan E Hodge

  • 1Department of Pediatrics, University of California Irvine Medical Center, Orange, California, pflodman@uci.edu.

Journal of Genetic Counseling
|July 5, 2015
PubMed
Summary
This summary is machine-generated.

Genetic counselors can now use a new computer-based likelihood approach for genetic risk calculations. This method, implemented with CYRILLIC and LINKAGE, aids in accurate genetic risk assessment.

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

35.0K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.7K

Related Experiment Videos

Last Updated: Apr 7, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

35.0K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.7K

Area of Science:

  • Genetics
  • Computational Biology
  • Medical Informatics

Background:

  • Genetic risk analysis is a core responsibility for genetic counselors.
  • Existing computer-based risk assessment tools are underutilized.

Purpose of the Study:

  • To present a novel computer-based likelihood approach for genetic risk calculations.
  • To demonstrate the implementation of this approach using specific software packages.

Main Methods:

  • Development of a computer-based likelihood framework for risk assessment.
  • Application of the framework using the CYRILLIC and LINKAGE computer packages.
  • Inclusion of Bayesian analysis within the likelihood approach.

Main Results:

  • Successful implementation of the computer-based likelihood approach.
  • Demonstration of risk calculations through concrete examples.
  • Discussion of important caveats for risk calculation programs.

Conclusions:

  • The presented computer-based likelihood approach offers a viable method for genetic risk assessment.
  • The CYRILLIC and LINKAGE packages facilitate the practical application of this approach.
  • Awareness and application of caveats are crucial for accurate genetic counseling.