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Hyperfiltration in Indigenous Australians with and without diabetes
Elif I Ekinci1, Jaquelyne T Hughes2, Mark D Chatfield2
1Menzies School of Health Research, Charles Darwin University, Darwin, Australia Department of Medicine, Austin Health and the University of Melbourne, Melbourne, Australia.
Summary
Hyperfiltration (HF) is present in Indigenous Australians, with or without diabetes. A higher percentage of individuals with HF also had diabetes, suggesting a potential link to kidney disease development.
Area of Science:
- Nephrology
- Diabetology
- Indigenous Health
Background:
- Diabetic kidney disease (DKD) is a significant health concern, particularly in Indigenous Australian populations.
- The role of hyperfiltration (HF) in DKD pathogenesis is not fully understood.
- No prior studies have investigated HF in Indigenous Australians.
Purpose of the Study:
- To compare the characteristics and frequency of HF in Indigenous Australians with and without type 2 diabetes.
- To assess the prevalence of HF across different definitions in this population.
Main Methods:
- A cohort of 383 Indigenous Australians was studied, stratified by health, diabetes, and kidney function.
- Measured glomerular filtration rate (mGFR) was determined using plasma disappearance of iohexol over 4 hours.
- HF was defined using multiple criteria, including absolute mGFR values and age-adjusted cut-offs.
Main Results:
- The prevalence of HF varied significantly based on the definition used, ranging from 7% to 27%.
- Diabetes was more prevalent in participants with HF (40-74%) compared to those with normal filtration (28-31%).
- HF was observed in both diabetic and non-diabetic Indigenous Australians.
Conclusions:
- Hyperfiltration is present in Indigenous Australians, irrespective of diabetes status.
- A higher proportion of individuals with HF had diabetes, indicating a potential association.
- Further longitudinal studies are required to ascertain HF's role in the development of DKD and non-DKD.
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