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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Association of metabolic syndrome with testosterone and inflammation in men
Chandima Madhu Wickramatilake1, Mohamed R Mohideen2, Chitra Pathirana1
1Department of Biochemistry, Faculty of Medicine, University of Ruhuna, P.O. Box: 70, Galle, Sri Lanka.
Objective:
There is limited data on the assessment of relationship between sex hormones, metabolic syndrome (MS) and inflammation. Therefore, our objective was to examine the relationship between metabolic syndrome, testosterone and inflammation.
Patients And Methods:
It was a cross-sectional study which included 309 subjects in the age range of 30-70years. Blood was analyzed for plasma glucose, serum lipids, total testosterone (TT) and high-sensitivity C-reactive protein (hs-CRP).
Results:
There were 153 patients with metabolic syndrome and 156 without MS according to modified NCEP guidelines. Age, BMI, obesity, dyslipidaemia, smoking (OR=2.35, CI=1.35-4.09), LDL-Ch, low TT (OR=0.76, CI=0.38-1.52) and elevated hs-CRP (OR=1.56, CI=0.87-2.80) were significant independent predictors of MS (all P<0.05).
Conclusions:
The low testosterone and high hs-CRP levels are independent predictors of metabolic syndrome.
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