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Updated: Apr 7, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
[Statins for children with hypercholesterolemia]
1Nutrition et gastro-entérologie pédiatriques, hôpital Armand-Trousseau, AP-HP, UPMC, 26, avenue Arnold-Netter, 75012 Paris 06, France.
Abstract:
In the different types of children's hypercholesterolemia, some severe inherited monogenic forms, transmitted as a dominant trait, carry a high risk of early cardiovascular events in young adults and a decrease in life expectancy, warranting the initiation of a preventive cholesterol-lowering treatment early in childhood. As in adult patients, statins are the first-line drugs. The purpose of this article is to review the existing recommendations for their indications in children, their benefits, their tolerance, as well as their prescription and monitoring modalities.
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