Endothelial monocyte activating polypeptide II in children and adolescents with type 1 diabetes mellitus: Relation to

Related Experiment Video

Updated: Apr 7, 2026

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.5K

Amira A M Adly1, Eman A Ismail2, Lamis M Tawfik2

  • 1Pediatric Department, Faculty of Medicine, Ain Shams University, Egypt.

Cytokine
|July 6, 2015
PubMed
Abstract

Insights

Endothelial monocyte-activating polypeptide II (EMAP II) is elevated in children with type 1 diabetes, especially those with micro-vascular complications. Higher EMAP II levels correlate with inflammation and poor glycemic control, indicating its potential as a complication marker.

Area of Science:

  • Endocrinology
  • Immunology
  • Nephrology

Background:

  • Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory and antiangiogenic polypeptide.
  • Hyperglycemia and dyslipidemia are linked to elevated EMAP II levels.
  • EMAP II's role in type 1 diabetes complications requires further investigation.

Purpose of the Study:

  • To determine serum EMAP II levels in children and adolescents with type 1 diabetes.
  • To assess EMAP II as a potential marker for micro-vascular complications.
  • To evaluate the relationship between EMAP II, inflammation, and glycemic control.

Main Methods:

  • Eighty children and adolescents with type 1 diabetes were grouped by micro-vascular complication status and compared to 40 healthy controls.
  • Serum levels of EMAP II, high-sensitivity C-reactive protein (hs-CRP), and hemoglobin A1c (HbA1c) were measured.
  • Micro-vascular complications included microalbuminuria and elevated serum creatinine.

Main Results:

  • Serum EMAP II levels were significantly higher in diabetic patients with (1539 ± 321.5 pg/mL) and without (843.6 ± 212.6 pg/mL) micro-vascular complications compared to controls (153.3 ± 28.3 pg/mL).
  • EMAP II levels positively correlated with BMI, fasting glucose, HbA1c, creatinine, lipids, urinary albumin-to-creatinine ratio (UACR), and hs-CRP.
  • A cutoff of 1075 pg/mL for EMAP II demonstrated 93% sensitivity and 82% specificity in differentiating patients with and without micro-vascular complications.

Conclusions:

  • EMAP II is elevated in type 1 diabetes patients, particularly those with micro-vascular complications.
  • EMAP II levels are associated with inflammation, glycemic control, and albuminuria.
  • EMAP II may serve as a valuable biomarker for predicting micro-vascular complications in type 1 diabetes.
Keywords:
EMAP IIMicro-vascular complicationsType 1 diabetes

More Related Videos

Assessing Endothelial Vasodilator Function with the Endo-PAT 200007:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.7K
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

14.1K

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.1K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.5K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.8K