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Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis
Published on: July 8, 2025
Factors associated with age at pyeloplasty in children with ureteropelvic junction obstruction
Vijaya M Vemulakonda1, Duncan T Wilcox, Timothy M Crombleholme
1Department of Pediatric Urology, Children's Hospital Colorado, 13123 E. 16th Ave, Campus Box B-463, Aurora, CO, USA, vijaya.vemulakonda@childrenscolorado.org.
Insights
Early pyeloplasty for UPJ obstruction in children is linked to patient and hospital factors. However, this early intervention increases the risk of hospital readmission within one year.
Area of Science:
- Pediatric Urology
- Health Services Research
Background:
- Ureteropelvic junction (UPJ) obstruction is a common cause of congenital hydronephrosis in children.
- Pyeloplasty is the gold standard surgical treatment for UPJ obstruction.
- Factors influencing the timing of pyeloplasty and its impact on outcomes require further investigation.
Purpose of the Study:
- To identify factors associated with performing pyeloplasty in children younger than one year.
- To determine if early pyeloplasty (before age one) increases the risk of hospital readmission.
Main Methods:
- Retrospective review of 4499 children (0-18 years) who underwent pyeloplasty for UPJ obstruction from 1999-2009.
- Utilized the Pediatric Health Information System (PHIS) database.
- Analyzed patient demographics, insurance, illness severity, and hospital characteristics using logistic regression and Cox proportional hazards models.
Main Results:
- Minority race, male gender, public insurance, high severity of illness, Southern region, and low hospital volume predicted early surgery.
- Early surgery was significantly associated with an increased risk of hospital readmission within one year (Hazard Ratio 2.42).
Conclusions:
- Patient demographic and hospital factors influence the timing of pyeloplasty in children with UPJ obstruction.
- Early surgical intervention for UPJ obstruction is associated with higher readmission rates, highlighting potential outcome disparities.
Objectives:
Our objectives were to: (1) delineate factors associated with surgery at <1 year and (2) determine if early intervention was associated with increased risk of readmission.
Methods:
We conducted a retrospective review of children age 0-18 years with a diagnosis of UPJ obstruction who underwent pyeloplasty from 1/1/1999 to 9/1/2009 using the PHIS database. Data collected included patient factors (race, gender, insurance type, APR-DRG severity of illness) and hospital factors (annual case volume, census region, academic status). Outcomes assessed were: age at surgery and hospital readmission within 1 year of surgery. Data were analyzed using logistic regression and Cox PH for multivariate analyses.
Results:
4499 children met study criteria. Minority race (OR 1.55), male gender (OR 1.49), public insurance (OR 1.37), high severity of illness (OR 3.60), Southern region (OR 1.44), and low hospital volume (OR 1.37) were significant predictors of early surgery (p < 0.05). Only early surgery (HR 2.42; 95% CI 1.67-3.49 2.42) was associated with increased risk of readmission.
Conclusions:
In children with UPJ obstruction, age at surgery is associated with patient demographic and hospital factors. Early surgery is associated with higher rates of readmission, suggesting that variations in age at surgery may be associated with significant differences in outcomes.
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