Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Body-Brain Integration: The Lower Brainstem in Sleep-Wake Regulation.

Annual review of neuroscience·2026

Same author

Social network analysis-informed peer champions for hand hygiene in the operating room: a cluster randomised controlled trial.

The Journal of hospital infection·2026

Same author

Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis.

Bone research·2026

Same author

A cholinergic mechanism orchestrating task-dependent computation across the cortex.

bioRxiv : the preprint server for biology·2025

Same author

Brainstem circuit for sickness-induced sleep.

Science advances·2025

Same author

Patterned wireless transcranial optogenetics generates artificial perception.

Nature neuroscience·2025

Same journal

Dynamic coordination and segregation mechanisms in higher cortex for parallel task processing.

Neuron·2026

Same journal

Higher-order thalamic bursts are drivers of attention control.

Neuron·2026

Same journal

Composing trajectories for rapid inference of navigational goals.

Neuron·2026

Same journal

Peri-head distance coding in the mouse brainstem.

Neuron·2026

Same journal

A two-timepoint framework for sensitive and specific single-cell activity screening.

Neuron·2026

Same journal

From first impressions to bonds: The neural dynamics of social relationships.

Neuron·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 7, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior.

Lucas Pinto¹, Yang Dan¹

¹Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

|July 7, 2015

Summary

This summary is machine-generated.

Different brain cell types in the prefrontal cortex (PFC) encode distinct aspects of goal-directed behavior. This research clarifies how specific interneuron subtypes and pyramidal neurons process sensory cues, actions, and outcomes.

More Related Videos

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Related Experiment Videos

Last Updated: Apr 7, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Area of Science:

Neuroscience
Cellular Biology
Cognitive Science

Background:

The prefrontal cortex (PFC) is critical for goal-directed behavior.
Understanding how different cell types within the PFC encode task-related information is essential but remains unclear.

Purpose of the Study:

To investigate the differential encoding of task-related signals by genetically defined cell types in the mouse dorsomedial PFC.
To elucidate the functional properties of interneuron subtypes and pyramidal neurons during a sensory discrimination task.

Main Methods:

Cellular-resolution microendoscopic calcium (Ca2+) imaging was employed.
Genetically defined cell types in the dorsomedial PFC of mice were studied.
Mice performed a PFC-dependent sensory discrimination task.

Main Results:

Somatostatin-positive interneurons primarily signaled motor actions (licking).
Vasoactive intestinal peptide-positive interneurons responded strongly to action outcomes.
Parvalbumin-positive interneurons showed less selectivity, responding to cues, actions, and outcomes.
Pyramidal neurons exhibited greater functional heterogeneity than interneuron subtypes and varied responses across cortical layers.

Conclusions:

Distinct inhibitory interneuron subtypes preferentially signal different task-related events.
Pyramidal neurons display significant functional heterogeneity, with layer-specific response variations.
Cell-type and laminar specificity in neuronal function are crucial for PFC microcircuit computations.