Related Experiment Video
Updated: Apr 7, 2026
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Use of dynamic light scattering and small-angle X-ray scattering to characterize new surfactants in solution
Mohamed Dahani1, Laurie Anne Barret1, Simon Raynal1
1Institut des Biomolécules Max Mousseron/CBSA, UMR 5247, Avignon University, 33 Rue Louis Pasteur, 84000 Avignon,France.
Abstract:
The structural and interactive properties of two novel hemifluorinated surfactants, F2H9-β-M and F4H5-β-M, the syntheses of which were based on the structure and hydrophobicity of the well known dodecyl-β-maltoside (DD-β-M), are described. The shape of their micellar assemblies was characterized by small-angle X-ray scattering and their intermicellar interactions in crystallizing conditions were measured by dynamic light scattering. Such information is essential for surfactant phase-diagram determination and membrane-protein crystallization.
