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Ocular inflammatory changes in established multiple sclerosis.

E M Graham1, D A Francis, M D Sanders

  • 1National Hospital for Nervous Diseases, London, United Kingdom.

Journal of Neurology, Neurosurgery, and Psychiatry
|December 1, 1989
PubMed
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Ocular inflammation, or uveitis, is common in multiple sclerosis (MS) patients, particularly those with severe disease. However, it is less frequent when optic atrophy is present, suggesting eye inflammation may indicate MS activity.

Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Ocular manifestations, including uveitis, can occur in MS patients.
  • The relationship between uveitis and disease severity/progression in MS requires further elucidation.

Purpose of the Study:

  • To determine the prevalence of concomitant uveitis in patients with clinically definite multiple sclerosis.
  • To explore the correlation between ocular inflammation and disease severity, progression, and optic atrophy in MS.

Main Methods:

  • Prospective study of fifty consecutive patients with clinically definite multiple sclerosis.
  • Clinical assessment for uveitis and optic atrophy.
  • Correlation analysis between ocular findings and disease characteristics.

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Main Results:

  • Eighteen percent (18%) of MS patients exhibited asymptomatic ocular inflammatory changes (uveitis).
  • Ocular inflammation showed a positive correlation with severe and progressive MS.
  • Uveitis was less common in patients with established optic atrophy.

Conclusions:

  • Ocular inflammation is a significant finding in multiple sclerosis, potentially indicating disease activity.
  • The absence of optic atrophy may be a prerequisite for the development of uveitis in MS.
  • Ocular inflammatory changes may serve as a valuable biomarker for disease activity in MS, especially in the absence of optic atrophy.