Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.2K
Protein Networks02:26

Protein Networks

2.9K
2.9K
Protein Networks02:26

Protein Networks

4.7K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.7K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

4.8K
4.8K
Genomics02:02

Genomics

41.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.8K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

15.1K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
15.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Immunothrombotic Extracellular Vesicle mRNA Profile Associated with Thrombosis in Lung Adenocarcinoma.

International journal of molecular sciences·2026
Same author

XPM Ultrafast Nanoindentation for Direct-Writing Lithography of SERS-Active Nanostructured Metallic Photonic Crystals: An Exploration from Instrumental Matters to Application Prospects.

The journal of physical chemistry letters·2026
Same author

Horizontal visibility graph analysis of melodic skylines in musical stimuli used in epilepsy research.

Chaos (Woodbury, N.Y.)·2026
Same author

Targeted KRASG12V Degradation in vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis.

Cancer research·2026
Same author

DNA damage/p53, innate immune, and unfolded protein responses are activated in primate liver after toxic, high-dose AAV-SMN1 delivery.

Molecular therapy. Advances·2026
Same author

Impact of Annealing on Perpendicular Magnetic Anisotropy and Interfacial Diffusion in Ultrathin [CoFeB/Pd]×n Multilayer Film.

Nanomaterials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Apr 7, 2026

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

1.5K

Proteogenomics Dashboard for the Human Proteome Project.

Daniel Tabas-Madrid1, Joao Alves-Cruzeiro1, Victor Segura2

  • 1ProteoRed-ISCIII, National Center for Biotechnology-CSIC (CNB) , C/Darwin 3, Madrid 28049, Spain.

Journal of Proteome Research
|July 7, 2015
PubMed
Summary
This summary is machine-generated.

The dasHPPboard integrates proteomics and transcriptomics data to advance human proteome mapping. This novel dashboard aids researchers in identifying missing proteins and understanding gene expression patterns.

Keywords:
ENCODEHuman Proteome ProjectRNA-Seqbioinformaticschromosome 16proteogenomicsproteomicsspHPPtranscriptomics

More Related Videos

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

10.2K
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Related Experiment Videos

Last Updated: Apr 7, 2026

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

1.5K
A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

10.2K
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Area of Science:

  • Proteomics
  • Genomics
  • Bioinformatics

Background:

  • The Spanish Human Proteome Project (SpHPP) consortium aims to map the entire human proteome.
  • Genomics projects like ENCODE provide valuable data on human cell lines.
  • Integrating multi-omics data is crucial for comprehensive proteome analysis.

Purpose of the Study:

  • To develop a novel proteomics-based dashboard, dasHPPboard, for the SpHPP.
  • To facilitate the mapping of the human proteome by integrating diverse experimental data.
  • To provide a resource for identifying missing proteins and understanding gene expression.

Main Methods:

  • Collected and processed shotgun and selected reaction monitoring proteomics data.
  • Integrated transcriptomics data from ENCODE and Human Body Map (HBM) projects.
  • Developed peptide databases using single nucleotide variants and RNA-Seq data for enhanced protein identification.

Main Results:

  • The dasHPPboard visualizes and shares integrated proteomic and transcriptomic data.
  • Identified gene expression patterns in cell lines and tissues, focusing on proteins with limited proteomic evidence.
  • Enabled sample-specific protein identification using custom peptide databases.

Conclusions:

  • The dasHPPboard serves as a valuable resource for proteogenomics analyses.
  • Facilitates the discovery and characterization of the human proteome.
  • Promotes data sharing and visualization for the HPP community.