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Updated: Apr 7, 2026

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
Published on: February 28, 2020
Classification and biology of tumour associated stromal cells
Lizzia Raffaghello1, Francesco Dazzi2
1Laboratory of Oncology, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy.
Abstract:
Stroma is a fundamental component of the tumour microenvironment whereby it supports malignant cell growth and spreading. It consists of different entities including cells of the immune system, vascular structures and fibroblasts. Much attention has recently been paid to fibroblasts since there is compelling evidence that they orchestrate the recruitment of and educate other cells to promote cancer growth. This review proposes to discuss in detail the nomenclature, origin, and biological functions of the different stromal cells residing in tumours.
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