Related Experiment Video
Updated: Aug 15, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Femoropopliteal bypass; factors influencing long term patency
Insights
Saphenous vein grafts show superior long-term patency compared to umbilical vein grafts in femoropopliteal bypass surgery for arterial occlusive disease. Graft type significantly impacts outcomes, influencing revascularization success.
Area of Science:
- Vascular Surgery
- Biomaterials Science
Background:
- Femoropopliteal bypass surgery is a critical intervention for peripheral arterial occlusive disease.
- Graft material selection is a key determinant of long-term surgical success.
Purpose of the Study:
- To compare the long-term patency rates of reversed saphenous vein grafts versus Dardick Biograft (umbilical vein grafts) in femoropopliteal bypass.
- To identify factors influencing graft patency in patients with arterial occlusive disease.
Main Methods:
- Retrospective analysis of 136 patients undergoing femoropopliteal bypass.
- Graft types included reversed saphenous vein (58%) and Dardick Biograft (42%).
- Evaluation of patency rates, graft failure, mortality, and influencing factors.
Main Results:
- Overall four-year graft patency was 62.2%.
- Saphenous vein grafts achieved a 74% patency rate, significantly higher than Dardick Biografts at 45%.
- Early graft failure was 4.8% for autologous veins vs. 33% for umbilical veins; distal anastomosis below the knee and poor arteriographic runoff were associated with lower patency.
Conclusions:
- Reversed saphenous vein grafts offer superior long-term patency compared to umbilical vein grafts for femoropopliteal bypass.
- Graft type is the most critical factor for successful revascularization in this patient cohort.
- Early failure of umbilical vein grafts was linked to a higher rate of amputations.
Abstract:
One hundred and thirty-six patients operated on with femoropopliteal bypass for arterial occlusive disease are retrospectively examined. In 58% of the cases the reversed saphenous vein was used, while 42% had a Dardick Biograft (umbilical vein graft). Patency rate for all grafts was 62.2% at four years. The most important factor for long term patency in our material is the type of graft used. In the saphenous vein group the four years patency rate was 74%, while in the Dardick group 45%. There was no significant difference in patency rate for patients operated on for claudication and those for limb salvage. We found a significantly lower patency rate when the distal anastomosis was placed below the knee. Patients with good arteriographic runoff had better long term patency. The difference was, however, not significant for the prosthetic group. The perioperative mortality was 1.4%. Early graft failure was 4.8% in the autologous vein group and 33% in the umbilical vein group. The majority of amputations occurred in patients with early failure of umbilical vein grafts.
Related Concept Videos
Peripheral Artery Disease I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease V: Postoperative Nursing Management

