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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Unified mild reaction conditions for C2-selective Pd-catalysed tryptophan arylation, including tryptophan-containing
Alan J Reay1, Thomas J Williams, Ian J S Fairlamb
1Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. ian.fairlamb@york.ac.uk.
Abstract:
Pd-mediated C-H bond functionalisation protocols have been designed and developed on tryptophan derivatives and tryptophan-containing peptides. The examination of different arylation reactions (three sets of different conditions A-C), all of which are notable for their low temperatures (≤40 °C), allowed identification of unified and complementary synthetic approaches toward a series of functionalised tryptophan-containing products. Tryptophan-containing peptides demonstrated to be susceptible to aromatic oxidation were successfully and selectively modified through the application of diaryliodonium salts in good yields.
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