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Relationship Between Mean Platelet Volume and Pulmonary Embolism in Patients With Deep Vein Thrombosis

Atilla Icli1, Fatih Aksoy2, Yasin Turker2

  • 1Department of Cardiology, Ahi Evran University Faculty of Medicine, Kirsehir, Turkey.

Heart, Lung & Circulation
|July 7, 2015
PubMed
Abstract

Insights

Mean platelet volume (MPV) is elevated in deep vein thrombosis (DVT) patients. Higher MPV levels are significantly associated with an increased risk of pulmonary embolism (PE) in DVT patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Diagnostic Biomarkers

Background:

  • Mean platelet volume (MPV) is linked to deep vein thrombosis (DVT).
  • The predictive role of MPV for pulmonary embolism (PE), a DVT complication, remains unclear.
  • This study investigates the association between MPV and acute PE in DVT patients.

Purpose of the Study:

  • To determine if MPV levels can predict pulmonary embolism in patients diagnosed with deep vein thrombosis.
  • To explore the correlation between elevated MPV and the incidence of PE in DVT patients.

Main Methods:

  • A comparative study involving three groups: DVT with PE (n=98), DVT without PE (n=97), and a control group (n=98).
  • DVT patients were categorized based on admission MPV: ≤9.15 fL (n=82) and >9.15 fL (n=113).

Main Results:

  • MPV was significantly higher in DVT patients compared to controls (9.3±0.9 fL vs 7.9±0.7 fL, p<0.001).
  • MPV was markedly elevated in DVT patients with PE versus those without PE (9.9±0.6 fL vs 8.7±0.7 fL, p<0.001).
  • Patients with DVT and MPV >9.15 fL had a substantially higher rate of PE (75.2%) compared to those with MPV ≤9.15 fL (15.9%, p<0.001).
  • Elevated MPV was an independent predictor of PE in DVT patients (OR: 22.19, 95%CI: 9.39-53.19, P<0.001).

Conclusions:

  • Elevated MPV levels are observed in patients with DVT.
  • Higher MPV values are significantly associated with an increased likelihood of pulmonary embolism in patients with DVT.
  • MPV may serve as a valuable biomarker for predicting PE risk in DVT patients.
Keywords:
Acute pulmonary embolismDeep vein thrombosisMean platelet volumePlatelet activationPlatelet count

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