Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

358
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
358
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

327
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
327
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

814
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
814
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

321
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
321
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

348
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
348

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophages in protective immunity to Hymenolepis nana in mice.

Immunology and cell biology·1992
Same author

Establishment of a folliculo-stellate-like cell line from a murine thyrotropic pituitary tumor.

Endocrinology·1992
Same author

The effects of sodium chloride, miso or ethanol on development of intestinal metaplasia after X-irradiation of the rat glandular stomach.

Japanese journal of cancer research : Gann·1992
Same author

Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons.

Journal of neurobiology·1992
Same author

The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum.

The EMBO journal·1992
Same author

Chemotactic factor in the pregnant rabbit uterine cervix.

American journal of obstetrics and gynecology·1992

Related Experiment Video

Updated: Apr 7, 2026

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.4K

Age-specific neuromuscular interaction during elderly habitual running.

K Sano1, M Akiyama1, M Hoffrén-Mikkola2

  • 1Osaka University of Health and Sports Sciences, Osaka, Japan.

Acta Physiologica (Oxford, England)
|July 7, 2015
PubMed
Summary

Elderly runners exhibit greater tendon strain and co-activation in lower-leg muscles compared to younger runners, indicating altered muscle activation patterns during running. This suggests elderly individuals may not activate muscles similarly to younger adults, impacting movement efficiency.

Keywords:
ageingco-activationlocomotiontendonultrasound

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.4K
Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

6.6K

Related Experiment Videos

Last Updated: Apr 7, 2026

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.4K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.4K
Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

6.6K

Area of Science:

  • Biomechanics
  • Gerontology
  • Exercise Physiology

Background:

  • Advancing age is associated with increased tendon compliance and shorter fascicle lengths.
  • Movement efficiency may be enhanced in older adults if muscle activation during dynamic movements matches that of younger adults.

Purpose of the Study:

  • To investigate age-specific behaviors of the medial gastrocnemius (MG) fascicles and tendinous tissues.
  • To examine lower-leg muscle activities in well-trained elderly runners compared to younger runners during treadmill running.

Main Methods:

  • Recruited 11 elderly (ELD) and 11 young (YOUNG) well-trained runners.
  • Measured MG fascicle length (Lfa) and tendinous tissue length (LTT) using ultrasonography during treadmill running at preferred speeds.
  • Simultaneously recorded kinematics and lower-leg muscle activities.

Main Results:

  • Elderly runners showed greater LTT during the entire contact phase compared to younger runners (P < 0.001).
  • Higher co-activation of lower-leg muscles was observed in ELD compared to YOUNG (P < 0.01).
  • ELD exhibited smaller changes in Lfa and greater LTT shortening during contact than YOUNG (P < 0.001).

Conclusions:

  • Elderly runners demonstrate different muscle activation patterns compared to younger runners.
  • These altered activation strategies in elderly runners may influence the utilization of tendon elasticity.
  • Findings suggest that elderly individuals may not activate muscles identically to younger adults during running.