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New method for the preparation of cyanoacrylic nanoparticles with improved colloidal properties
V Lenaerts1, P Raymond, J Juhasz
1Faculté de pharmacie, Université de Montréal, Québec, Canada.
Journal of Pharmaceutical Sciences
|December 1, 1989
Abstract:
The purpose of this study was to prepare nanoparticles with a size significantly smaller than 0.1 micron. It was shown that when sulphur dioxide was dissolved in the cyanoacrylic monomer at a high concentration, subsequent anionic polymerization in an aqueous phase produced particles as small as 10 nm. Moreover, the obtained particles displayed an important negative charge which improve their stability against aggregation. Finally, nanoparticles were successfully prepared in double-distilled water, thereby avoiding the use of dextran which can induce anaphylactoid reactions.