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[The cortical EEG in the acallosal mouse].

Y Okada1, T Negi, Y Hori

  • 1Department of Physical Education, Faculty of Education, Kagawa University, Takamatsu-city, Japan.

Nihon Seirigaku Zasshi. Journal of the Physiological Society of Japan
|January 1, 1989
PubMed
Summary

Mice lacking a corpus callosum show altered brainwave patterns. Complete absence of the corpus callosum significantly reduces EEG correlations, while partial absence shows no significant changes compared to normal mice.

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Area of Science:

  • Neuroscience
  • Comparative Anatomy
  • Neurophysiology

Context:

  • Congenital absence of the corpus callosum (ACC) is a rare neurological condition.
  • The ddN mouse strain exhibits spontaneous ACC, allowing for in-vivo studies.
  • ACC presents morphologically as complete agenesis or partial agenesis (genu/splenium).

Purpose:

  • To investigate differences in cortical electroencephalogram (EEG) spectral characteristics in normal, hypogenesis, and acallosal mice.
  • To correlate EEG findings with the morphological variations of the corpus callosum.

Summary:

  • Cortical EEG spectral characteristics were analyzed in 75 adult ddN mice (normal, hypogenesis, complete acallosal).
  • Electrodes were implanted to record EEG, and correlation coefficients were analyzed.

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  • Complete acallosal mice (n=11) showed significantly lower correlation coefficients in crossed contralateral, left vs. right hemispheres, and posterior homotopic regions (p<0.05).
  • Mice with hypogenesis of the corpus callosum (n=7) exhibited no significant EEG correlation differences compared to normal mice (n=57).

    • Impact:

    • This study reveals that complete absence of the corpus callosum significantly impacts interhemispheric EEG correlations.
    • Partial agenesis of the corpus callosum does not appear to affect these specific EEG measures.
    • Findings contribute to understanding the functional role of the corpus callosum in brain connectivity and EEG activity.