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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates
Lei Zhang1, Yecheng Li, Zexun Jin
1Department of Chemistry, The Chinese University of Hong Kong, Sha Tin, N.T., Hong Kong SAR, China. jimyu@cuhk.edu.hk.
Abstract:
Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.
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