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Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course.

Cynthia Gray1, Carol W Price1, Christopher T Lee1

  • 1Department of Chemistry, University of Virginia, Charlottesville, Virginia, 22904.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology
|July 7, 2015
PubMed
Summary

This study introduces an inquiry- and research-based undergraduate biochemistry lab curriculum. The new approach improved student performance and confidence in biochemical research skills.

Keywords:
active learningbiochemistry laboratorycurriculumfunctional genomicsinquiry-based learningprotein functionundergraduate research

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Area of Science:

  • Biochemistry Education
  • Undergraduate Laboratory Curriculum
  • Scientific Research Training

Background:

  • Traditional undergraduate biochemistry labs often lack authentic research experiences.
  • Instructional labs can be enhanced through inquiry- and research-based approaches.
  • This can improve scientific knowledge, research expertise, and student confidence.

Purpose of the Study:

  • To develop and evaluate a year-long undergraduate biochemistry laboratory curriculum.
  • To integrate authentic research experiences into instructional biochemistry labs.
  • To foster student expertise and confidence in biochemical research.

Main Methods:

  • A modular, inquiry-based first semester focused on general biochemical techniques.
  • A second semester where students conduct independent, original research projects.
  • Utilized experimentation and computation to determine protein function.

Main Results:

  • The curriculum demonstrated improvements in student performance.
  • Student confidence in biochemical research skills was significantly enhanced.
  • A freely accessible online resource was created to share teaching materials.

Conclusions:

  • An inquiry- and research-based curriculum effectively enhances undergraduate biochemistry education.
  • This model successfully bridges instructional goals with authentic research experiences.
  • The developed curriculum and resources are valuable for educators and students.