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Effects of moderate- and high-intensity chronic exercise on brain-derived neurotrophic factor expression in fast and
Alberto Jiménez-Maldonado1, Joel Cerna-Cortés2, Elena M Castro-Rodríguez1
1Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, 965 Ave. 25 de Julio, Col. Villas San Sebastián, Colima, 28045, México.
Introduction:
Brain-derived neurotrophic factor (BDNF) protein expression is sensitive to cellular activity. In the sedentary state, BDNF expression is affected by the muscle phenotype.
Methods:
Eighteen Wistar rats were divided into the following 3 groups: sedentary (S); moderate-intensity training (MIT); and high-intensity training (HIT). The training protocol lasted 8 weeks. Forty-eight hours after training, total RNA and protein levels in the soleus and plantaris muscles were obtained.
Results:
In the plantaris, the BDNF protein level was lower in the HIT than in the S group (P < 0.05). A similar effect was found in the soleus (without significant difference). In the soleus, higher Bdnf mRNA levels were found in the HIT group (P < 0.001 vs. S and MIT groups). In the plantaris muscle, similar Bdnf mRNA levels were found in all groups.
Conclusions:
These results indicate that high-intensity chronic exercise reduces BDNF protein level in fast muscles and increases Bdnf mRNA levels in slow muscles.
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