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Updated: Apr 7, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
RNA-sequencing based identification of crucial genes for esophageal squamous cell carcinoma
Jian-Hua Fu, Li-Quan Wang1, Tao Li
1Department of Thoracic Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, China.
Aims:
To identify key genes and pathways in the development of esophageal squamous cell carcinoma with RNA-seq data.
Materials And Methods:
RNA-seq data including three paired samples were downloaded from Sequence Read Archive database under accession number SRP007169 and differentially expressed genes (DEGs) were identified with package edge R of R. Functional enrichment analysis was performed to uncover their biological functions with the Database for Annotation, Visualization, and Integrated Discovery (DAVID) tools.
Results:
A total of 5561 DEGs were obtained, including 1829 upregulated and 3732 downregulated. Quite a few upregulated genes were components of collagen and matrix metallopeptidases (MMPs), which are involved in cell adhesion, cell mobility and so on. Keratin, mucin and cysteine-rich secretory protein were found to be significantly downregulated. Significantly over-represented biological processes for downregulated genes were epidermis development, epidermal cell differentiation and arachidonic acid metabolism.
Conclusion:
These identified DEGs may be underlying targets for diagnosis and treatment of esophageal squamous cell carcinoma.
