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Related Experiment Videos

Reversible cardiomyopathy due to selenium deficiency.

W C Reeves1, S P Marcuard, S E Willis

  • 1East Carolina University, School of Medicine, Greenville, North Carolina 27834.

JPEN. Journal of Parenteral and Enteral Nutrition
|November 1, 1989
PubMed
Summary

Selenium deficiency can cause heart disease (cardiomyopathy), particularly in children. This case study shows selenium supplementation reversed cardiomyopathy in a woman with Crohn's disease, highlighting its importance for heart health.

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Area of Science:

  • Biochemistry
  • Cardiology
  • Nutritional Science

Background:

  • Selenium is an essential trace element vital for glutathione peroxidase activity, an enzyme protecting against cellular oxidative damage.
  • Selenium deficiency is associated with Keshan disease, a form of dilated congestive cardiomyopathy primarily affecting children in rural China.
  • Deficiency cases are sporadically reported in the US, often linked to poor nutritional intake or long-term home parenteral nutrition.

Observation:

  • A young Black woman with Crohn's disease developed congestive cardiomyopathy.
  • Her cardiac condition was diagnosed and monitored.

Findings:

  • The patient's congestive cardiomyopathy was reversed after selenium administration.
  • This suggests a direct link between selenium status and cardiac function in this patient.

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Implications:

  • This case highlights the critical role of selenium in preventing and treating cardiomyopathy, even in adults with chronic conditions.
  • It underscores the importance of assessing selenium levels in patients with unexplained cardiomyopathy, especially those with malabsorption disorders like Crohn's disease.
  • Adequate selenium intake is crucial for maintaining cardiovascular health and preventing severe cardiac complications.