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Related Experiment Videos

Left ventricular pump function in right ventricular overload.

Y Maruyama1, N Ito, H Kinoshita

  • 1First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Japanese Circulation Journal
|October 1, 1989
PubMed
Summary

Right ventricular overload in cor pulmonale does not always impair left ventricular pumping. Left ventricular systolic function is maintained unless both ventricles experience significantly elevated diastolic pressures simultaneously.

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Area of Science:

  • Cardiovascular Physiology
  • Experimental Cardiology

Background:

  • Cor pulmonale, characterized by right ventricular overload, can affect left ventricular function.
  • Understanding the mechanisms of left ventricular alteration in cor pulmonale is crucial for patient management.

Purpose of the Study:

  • To investigate how right ventricular overload influences left ventricular pumping action.
  • To determine the conditions under which left ventricular systolic function is compromised in cor pulmonale models.

Main Methods:

  • Utilized both excised perfused canine hearts (n=16) and in vivo canine models (n=6).
  • Induced right ventricular overload via pulmonary artery constriction, femoral arterial-venous shunt, and right coronary artery occlusion.
  • Assessed left ventricular systolic function using pressure-volume relationships in excised hearts and 2D echocardiography in vivo.

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Main Results:

  • In excised hearts, left ventricular developed pressure decreased significantly with elevated right and left ventricular diastolic pressures.
  • In vivo, right ventricular overload from pulmonary constriction and shunt increased left ventricular ejection fraction due to afterload reduction.
  • Right coronary artery occlusion led to decreased left ventricular ejection fraction despite similar afterload reduction compared to pulmonary constriction.

Conclusions:

  • Right ventricular overload alone does not necessarily cause left ventricular systolic dysfunction.
  • Left ventricular systolic dysfunction occurs when both right and left ventricular end-diastolic pressures rise significantly and simultaneously.