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Hyperbranched poly(glycidol)/poly(ethylene oxide) crosslinked hydrogel for tissue engineering scaffold using e-beams.

Haryanto1,2, Deepti Singh3, Pil Ho Huh4

  • 1Department of Chemical Engineering, Muhammadiyah University of Purwokerto, Central Java, 53182, Indonesia.

Journal of Biomedical Materials Research. Part A
|July 8, 2015
PubMed
Summary

A novel microporous hydrogel scaffold made from hyperbranched poly(glycidol) (HPG) and poly(ethylene oxide) (PEO) was developed using electron beam cross-linking. This HPG/PEO hydrogel shows promise for tissue engineering applications due to its tunable properties and biocompatibility.

Keywords:
electron beamhydrogelhyperbranched poly(glycidol)microporous scaffoldtissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Hydrogel scaffolds are crucial for tissue engineering.
  • Developing biocompatible and tunable scaffolds is essential.
  • Electron beam cross-linking offers a controlled method for hydrogel fabrication.

Purpose of the Study:

  • To develop a microporous hydrogel scaffold using hyperbranched poly(glycidol) (HPG) and poly(ethylene oxide) (PEO).
  • To investigate the effects of varying HPG content on scaffold properties.
  • To evaluate the potential of the HPG/PEO hydrogel for tissue engineering applications.

Main Methods:

  • Synthesis of HPG using glycidol and trimethylol propane.
  • Fabrication of cross-linked HPG/PEO hydrogels with varying HPG percentages (0-30%) via e-beam irradiation.
  • Characterization of swelling ratio, cross-linking density, mechanical properties, morphology, degradation, and cytotoxicity.

Main Results:

  • Increasing HPG content enhanced pore size, porosity, elongation at break, degradation, and swelling ratio.
  • HPG addition decreased cross-linking density but did not significantly alter compressive modulus or tensile strength.
  • HPG/PEO hydrogels exhibited good biocompatibility, supporting cellular attachment and proliferation.

Conclusions:

  • HPG/PEO hydrogels offer tunable pore sizes and mechanical properties for tissue engineering scaffolds.
  • E-beam irradiation provides a facile method for preparing these microporous hydrogel scaffolds.
  • The developed HPG/PEO hydrogel is a promising biomaterial for tissue engineering applications.