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The Inhibitor Ko143 Is Not Specific for ABCG2

Lora D Weidner1, Sami S Zoghbi2, Shuiyu Lu2

  • 1Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland (L.D.W., S.S.Z., S.L., V.W.P., R.B.I.); Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden (L.D.W., J.M.); and Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland (S.S., S.V.A., M.M.G., M.D.H.) lora.deuitch@nih.gov.

The Journal of Pharmacology and Experimental Therapeutics
|July 8, 2015
PubMed
Summary

Ko143 is a potent inhibitor of ABCG2 transporter, but it also affects ABCB1 and ABCC1 transporters at higher concentrations. This compound is also unstable in rat plasma, limiting its use in experiments.

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