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Fibrinogen, red blood cells, and factor XIII in venous thrombosis

B L Walton1, J R Byrnes1, A S Wolberg1

  • 1Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Journal of Thrombosis and Haemostasis : JTH
|July 8, 2015
PubMed

Insights

Venous thrombosis (VT) is a major cause of death. This review explores how fibrinogen, factor XIII, and red blood cells interact to form and stabilize venous thrombi, improving understanding of VT pathology.

Area of Science:

  • Biochemistry
  • Hematology
  • Cardiovascular Research

Background:

  • Cardiovascular disease is a leading global cause of mortality.
  • Venous thrombosis (VT) is the third most common cause of cardiovascular death.
  • The precise mechanisms governing venous thrombus composition and stability remain incompletely understood.

Purpose of the Study:

  • To review the biological, biochemical, and biophysical roles of key components in VT.
  • To explore the interactions between fibrinogen, factor XIII, and red blood cells in VT.
  • To present new evidence on how these interactions influence thrombus characteristics.

Main Methods:

  • Literature review of existing biological, biochemical, and biophysical studies.
  • Analysis of current research on fibrinogen, factor XIII, and red blood cells in thrombosis.
  • Synthesis of new evidence regarding component interactions in venous thrombus formation.

Main Results:

  • Fibrinogen, factor XIII, and red blood cells significantly contribute to VT.
  • Interactions between these components are crucial for thrombus composition and size.
  • Understanding these interactions offers new insights into VT pathophysiology.

Conclusions:

  • Fibrinogen, factor XIII, and red blood cells are key determinants of venous thrombus characteristics.
  • Interactions among these elements are critical for thrombus formation and stability.
  • Further research into these interactions may reveal novel therapeutic targets for VT.

Keywords:
clot retractionfactor XIIIfibrinogenplateletred blood cellvenous thrombosis

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