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[Clinical experience with cefixime in urinary tract infections]
The Japanese Journal of Antibiotics
|December 1, 1989
Summary
Cefixime demonstrated high efficacy in treating acute uncomplicated cystitis (100%) and moderate efficacy in complicated urinary tract infections (63%). This oral cephem antibiotic showed good safety, with minimal adverse effects in patients.
Area of Science:
- Pharmacology
- Urology
- Infectious Diseases
Context:
- Urinary tract infections (UTIs) are common, necessitating effective antimicrobial treatments.
- Oral cephem antibiotics offer a convenient treatment option for UTIs.
- Evaluating new antibiotics like Cefixime is crucial for managing UTIs.
Purpose:
- To assess the therapeutic effectiveness and safety of Cefixime in treating UTIs.
- To determine Cefixime's efficacy in both acute uncomplicated cystitis and complicated UTIs.
- To evaluate the bacteriological eradication rates and adverse reactions associated with Cefixime.
Summary:
- Cefixime (200 mg daily) was administered to 129 UTI patients.
- Excellent to moderate clinical efficacy was observed in 100% of acute uncomplicated cystitis cases and 63% of complicated UTI cases.
- Bacteriological eradication rates were 100% for uncomplicated UTIs and 79% for complicated UTIs, with a 3.1% incidence of mild adverse reactions.
Impact:
- Cefixime is a potentially effective oral treatment for various urinary tract infections.
- The study provides valuable data on Cefixime's clinical performance and safety profile.
- Findings support Cefixime's use in urological practice for UTI management.