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Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
Published on: February 18, 2020
Controlling drug delivery from coronary stents: are we aiming for the right targets?
Anne Seidlitz1, Monika Wentzlaff1, Werner Weitschies1
1Institute of Pharmacy, Center of Drug Absorption & Transport, University of Greifswald, Felix-Hausdorff-Straße 3, 17487 Greifswald, Germany.
Abstract:
In this review article, the currently employed or explored delivery concepts for local intravascular drug delivery with drug-eluting stents (DES) are discussed with a special emphasis on clinical evidence regarding the desired release profiles. Traditional concepts to control drug release from DES include diffusion through polymers, polymer degradation and erosion as well as dissolution of particulate drug. Published clinical studies do not always reveal fine mechanistic details. The long duration of release favored for DES and the short duration of release favored for drug-eluting balloons require further investigation in experimental studies and clinical trials.
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