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[Outburst of fusidic acid resistant Staphylococcus aureus]
Abstract:
Fusidic acid (FA) resistance (MIC greater than or equal to 12.5) was found in only five of 123 strains of S. aureus isolated during the period from January, 1987, to March, 1988; the FA resistance rate soared up to 42 of 81 strains isolated during the period from April, 1988, to October, 1988. In contrast, all strains of S. aureus isolated in Kochi prefecture during the period from September, 1987, to September, 1988, were susceptible to FA. Our data clearly demonstrate an explosive increase of FA resistant S. aureus in Japan. However, regional differences currently exist in the emergence rate of FA resistant S. aureus.
Insights
Fusidic acid resistance in Staphylococcus aureus has dramatically increased in Japan. Regional variations in this concerning trend of antibiotic resistance were observed.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Staphylococcus aureus (S. aureus) is a common cause of bacterial infections.
- Fusidic acid (FA) is an antibiotic used to treat S. aureus infections.
- Monitoring antibiotic resistance is crucial for effective treatment strategies.
Purpose:
- To investigate the prevalence and trends of fusidic acid resistance in S. aureus strains in Japan.
- To identify potential regional differences in the emergence of FA resistance.
Summary:
- A significant increase in fusidic acid resistance among S. aureus strains was observed in Japan between 1987 and 1988.
- Initially, low resistance rates (5/123 strains) rose sharply to 42/81 strains within months.
- Conversely, S. aureus strains from Kochi prefecture remained susceptible to FA during the study period.
Impact:
- The findings highlight an alarming surge in FA-resistant S. aureus in Japan.
- This indicates a potential public health concern requiring further investigation and intervention.
- Regional disparities in resistance emergence suggest localized factors influencing antibiotic resistance development.