Related Experiment Video

Updated: Apr 7, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

9.1K

Phosphoinositide signaling in cancer: INPP4B Akt(s) out

John F Woolley1, Irakli Dzneladze2, Leonardo Salmena1

  • 1Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Trends in Molecular Medicine
|July 8, 2015
PubMed

Insights

Inositol polyphosphate-4-phosphatase type II (INPP4B) typically suppresses tumors but surprisingly promotes them in certain cancers. This review explores INPP4B's dual role in cancer signaling.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Inositol polyphosphate-4-phosphatase type II (INPP4B) is recognized for its tumor-suppressive functions in epithelial cancers.
  • INPP4B functions by inhibiting the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling pathway, a critical regulator of cell growth and survival.

Purpose of the Study:

  • To explore the paradoxical roles of INPP4B in cancer.
  • To discuss the dual functions of INPP4B in both tumor suppression and promotion across different cancer types.

Main Methods:

  • Literature review and analysis of existing research on INPP4B.
  • Examination of INPP4B's signaling pathways in various cancer contexts.

Main Results:

  • INPP4B exhibits tumor-suppressive activity in epithelial cancers by inhibiting PI3K/Akt signaling.
  • Recent findings reveal unexpected tumor-promoting roles for INPP4B in leukemia and breast cancer.

Conclusions:

  • The function of INPP4B in cancer is context-dependent, displaying both tumor-suppressive and tumor-promoting activities.
  • Understanding the paradoxical nature of INPP4B signaling is crucial for developing targeted cancer therapies.
Keywords:
AktINPP4BPI3Koncogenephosphoinositidetumor suppressor

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.5K
Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation10:52

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation

Published on: January 6, 2016

10.9K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.4K
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
10.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.7K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
14.0K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
16.0K